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( Studies in Subjects With Mild Cognitive Impairment In a randomized, double-blind, placebo-controlled crossover study, 6 months followed by another 6 months of open-label extension of MCT (C8) supplementation with up to 42 g a day (25.2 g on average), given with meals, improved some cognitive assessment scores in elderly subjects with mild to moderate dementia ( Studies in Alzheimer's Disease Patients A PET study in Alzheimer's Disease (AD) patients demonstrated that 1 month of daily consumption of 30 g of MCT (C8+C10 or C8) led to mild ketonemia and increased total brain energy metabolism due to an increase in ketone body utilization ( Several studies of MCT supplementation in AD patients showed that the intervention efficacy depended on APOE4 status

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Park JS, Yamamoto W, Sekikawa T, Matsukawa M, Okamoto R, Sasaki M, Ukon K, Tanimoto K, Kumazaki T, Nishiyama M (2002) Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers