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Later, in the 1980s, the development of high-pressure liquid chromatography methods allowed for rapid determination of homocysteine concentrations in 1000s of samples, thus paving the way for epidemiological studies that revealed significant associations between relatively small elevations of homocysteine in blood and cardiovascular, cerebrovascular, and peripheral vascular diseases (7, 46)

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When it is injected into the body it doesn't tax the body with the need for conversion

Extracellular vesicles: exosomes, microvesicles, and friends