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The histological tests of the spleen, liver, lung, kidney, or heart showed no pronounced degradation to these organs compared to their control sample groups, which confirms that PENs can be used as a drug delivery nano-system, improving drug efficacy and lessening the toxicity of drugs (111) showed that GDNVs loaded with Doxorubicin (Dox) released their cargo in an acidic-like tumor microenvironment, and the GDNVs allowed an increased diffusion of the Dox more than the commonly used commercial liposomes

Int Immunopharmacol 98:107844 Yan R, Xie E, Li Y, Li J, Zhang Y, Chi X, Hu X, Xu L, Hou T, Stockwell BR, Min J, Zhou Q, Wang F (2022) The structure of erastin-bound xct-4f2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis