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The binding of AGEs to their membrane receptors triggers downstream signaling pathways, promoting oxidative stress, chronic inflammation, hyperandrogenemia, insulin resistance, and anovulatory dysfunction (80)

It also acts as a neurotransmitter in the nervous system and plays a role in immunomodulation, inflammation and bile excretion

However, the efficacy of these methods fails to satisfy the demands of patient prognosis

Larazotide's barrier-restoration effect addresses the bidirectional gut-oral microbiome relationship strengthening the mucosal defense layer that systemic inflammation and periodontal disease progressively erode