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-KG is considered an important cofactor for enzymes participating in epigenetic modification 26

Abstract The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century

doi: 10.3109/10715762.2010.490837 19 CostaP

Owing to the association between OPTN and ANKIB1 at the TLR3-SC and prior evidence implicating OPTN as TBK1 adaptor in TLR3 signalling 32,37,38 , we next generated quadruple knockout (QKO) cells lacking TANK, NAP1, SINTBAD and OPTN