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Their clinical assessment relies on a combination of objective metrics and subjective measures, with self-report instruments such as the Fatigue Severity Scale and the CFQ being readily available and straightforward to administer

Some irAEs, such as thyroid disease, are treatable and the damage reversible

Pro-inflammatory cytokines induce mitophagy as a protective response, and mitophagy-deficient -cells accumulated dysfunctional mitochondria and had increased cell death, whereas overexpression of Clec16 rescued viability and mitophagy in human -cells (Sidarala et al., 2020)