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The release of IL-1 and TNF- can lead to a reduction in the expression of TJs and facilitate the engulfment of ECs by microglial cells [133, 134]

The ligand docking wizard which uses the glide module of the Schrdinger software (Schrdinger, 2022-2 suite), was used to carry out this analysis 63

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Human umbilical vein endothelial cells (HUVEC) were maintained in culture and exposed to 15% serum from each study group after a period of serum deprivation