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For instance, aged nave CD4+ T cells are not only reduced in number but also display dysfunctional one-carbon metabolism, the most induced metabolic pathway during the early stage of T cell activation

doi: 10.1007/s00223-006-0155-7

Key Points The insulin-like growth factor (IGF) binding proteins (IGFBPs) are a family of six proteins that function as transport proteins for IGF-I and IGF-II in the circulation and also regulate their access to the potentially oncogenic IGF-I receptor (IGF1R)