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Next, JC-1, a dual emission cationic dye was used to indirectly evaluate changes in the mitochondrial membrane potential (MMP) (Fig

54,55 and rivastigmine commercialized as Prometax in the form of tablets (1.5 mg, 3 mg, 45 mg, 6 mg), 56 and as Exelon available in capsules (1.5 mg, 3 mg, 4.5 mg, and 6 mg) oral solution (2mg/mL) and as a transdermal patch (4.6 mg, 9.5 mg, and 13.3 mg)

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Our data strongly suggests that NatA depletion caused faster protein degradation by enhancing the endogenous ubiqitination rate and increasing the capacity of the proteasome as shown by enhanced abundance and activity of the proteasome in soluble protein extracts