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2015 measured permeation through human skin samples held in a Franz cell apparatus, not living skin on a living person 3

Emerging evidence suggests that Nrf2 can enhance the expression of rhythm-inhibiting genes such as cryptochrome 2 and Rev-Erb in the nucleus, thereby indirectly inhibiting transcription mediated by the CLOCK-BMAL1 complex [103]

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Nevertheless, triatomine vectors exploit heme crystallization into hemozoin as a prime redox regulator mechanism that protects the insect itself, but also promotes parasite infection (Ferreira et al., 2018)