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However, the study lacked essential methodological details, including dosage and treatment duration, limiting the reproducibility and interpretability of the findings (Kaushik et al., 2018)

Biol Reprod

Nobody is really sure where the 3 months they use for maintenance in the UK comes from - in germany it is one month - one theory is that it was a response to a study in the 1960s which showed that taken as an average people retain hydroxo twice as long as cyano - which was used as monthly shots

Thats because vitamin B12 is bound to protein and can only be released by digestive substances in the stomach (hydrochloric acid and gastric protease) to be absorbed