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American Medical Association American Gastroenterological Association American Association For The Study of Liver Diseases Lafaine Grant, M.D

The study showed that activation of PPAR stimulated mitochondrial biogenesis and suppressed ROS production, protecting the brain from mitochondrial and oxidative damage (90)

Abbreviations in the Examples are as follows: mM = millimolar uM = micromolar uL = micro liter GAP = glutamate and cystine and glycine mix GAP 5 = 4 uM sodium pyroglutamic acid, 5 uM cystine, 16 uM glycine GAP 10 = 8 uM sodium pyroglutamic acid, 10 uM cystine, 32 uM glycine GAP 20 = 16 uM sodium pyroglutamic acid, 20 uM cystine, 64 uM glycine NaPCA = sodium pyroglutamic acid (also known as sodium pyrrolidonecarboxylic acid) HR=4-hexylresorcinol BR=4-butylresorcinol IPR = 4-isopropylresorcinol ER = 4-ethylresorcinol PER = 4- (1-phenylethyl) resorcinol MR = 4-methylresorcinol 4-CHMR = 4- (cyclohexylmethyl) resorcinol DEC = Diethyl L-cystinate dihydrochloride CDME = L-Cystine dimethyl ester dihydrochloride DTBC = Ditert-butyl L-cystinate dihydrochloride Example 1 Example 1 evaluated various combinations of 4-alkyl resorcinols and amino acids constituting GSH building blocks for potentiating intracellular GSH production

Serrano-marco L, Barroso E, El kochairi I, et al