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M2 microglia promotes the release of anti-inflammatory factors, such as TGF- and IL-10, while M1 microglia plays an opposite role ( D2R Several lines of evidences suggest that D2R signaling alleviates neuroinflammatory injury by CRYAB/STAT3 pathway, -arrestin2/NLRP3 pathway, and its regulation of macrophage phagocytic activity ( via increasing the extracellular glutamate levels ( via decreasing the microglial AT1/AT2 ratio, thus inhibiting AT1/NADPH-oxidase/superoxide axis, based on AT1-D2R heteromers ( D3R Genetic deficiency of D3R, attenuated neuroinflammation and subsequent neurodegeneration on a murine model of PD induced by acute intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( However, experimental results showed decreased D3R expression on CD4+ T cells in the peripheral circulation of PD patients, which might be due to a compensatory mechanism attempting to reduce the inflammatory effect ( Striatum D3R D3R expressed on striatal neurons can raise dopamine concentration, decrease -Syn accumulation, enhance secretion of BDNF, ameliorate neuroinflammation, alleviate oxidative stress, and promote neurogenesis in the nigrostriatal pathway