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469 The mitochondrial protein sideroflexin 1 (SFXN1) is responsible for importing iron from the cytoplasm to the mitochondria, and SFXN1 deficiency leads to mitochondrial respiratory chain damage, affecting the biogenesis and assembly of complex III

Although protein-SSG formation occurs by nonenzymatic mechanisms, the de-glutathionylation of proteins is mainly catalyzed by Grxs 32

This protein can create an iron-overloaded environment and lay the foundation for the occurrence of cellular ferroptosis

All searched spectra were imported into Scaffold (v5.3, Proteome Software) and scoring thresholds were set to achieve a peptide false discovery rate of 1% using the PeptideProphet algorithm