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For instance, deoxycholic acid has been shown to inhibit colonic epithelial recovery in vivo[70] and is linked to increased neutrophilic infiltration and higher inflammation scores in animal models[71]

RPE cells rely on mitochondria for energy production, performing oxidative phosphorylation and reductive carboxylation, a unique form of mitochondrial energy production that produces TCA cycle intermediates during hypoxic conditions [58,59,60]

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