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This includes a validated diagnostic algorithm called the SLE Risk Probability Index (SLERPI) where a SLERPI score of greater than 7 was highly accurate (94.2%) and sensitive for detecting early disease (93.8%) and severe manifestations including kidney (97.9%) and neuropsychiatric involvement (91.8%) (189)

Thereafter, the AMP monomers will self-aggregate into the -helix polymer with their hydrophilic side constituting the barrel-like hollow channel and insert into the hydrophobic membrane cores more deeply, forming transient transmembrane pores which may disrupt the ion gradients and transmembrane potential and eventually lead to cell death

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