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In order to assess the study level risk of bias, we used the modified Cochrane risk of bias tool [22], and we evaluated the certainty of the evidence using the GRADE [20]

Dopaminergic Agents Drugs that increase dopamine signaling, including pramipexole (Mirapex), ropinirole (Requip), and transdermal rotigotine (Neupro), as well as levodopa plus carbidopa (Sinemet), were historically recommended as first-line therapies for RLS and have well-established efficacy (Dopp 2026

Supplement alternatives to ALA If youre exploring options beyond alpha-lipoic acid for nerve health or oxidative stress, two of the most studied and promising alternatives are vitamin B12 and acetyl-L-carnitine (ALCAR).56 Each plays a unique role in nerve protection and repair, particularly in the context of diabetic neuropathy

We have produced a large-scale computational biology analysis of the SNO-proteome in the cortex of Shank3 mutant mice (a popular model of ASD [171, 282, 283]) and found that among the NO-related molecular alterations, the most prominent change was the activation of the mTOR signaling pathway [171, 176]