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[0314] In some embodiments, the compositions of the disclosure comprise between about 1 M and 10 mM of mitophagy stimulant (e.g., urolithin A)

By reducing NMDA excitotoxicity, Pinealon could help preserve penumbral tissue during the critical hours following stroke onset

10.3389/fendo.2015.00170 63 RbsamA.ParikhS.FortP

The high abundance and rapid and steady increase of glutathione observed in this study indicate that oxidized GSSG can serve as the oxidant for class III peroxidases for ROS production