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XCT is associated with unfavorable prognosis for various types of tumors, including HCC, colorectal cancer, and GBM [202, 203]
In this process, iron ions (Fe 2+ ) promote lipid oxidation in a Fenton-like reaction, increasing ROS levels alongside with intracellular glutathione (GSH) depletion, leading to the impairment of the activity of glutathione peroxidase 4 (GPX4), a GSH-dependent hydroperoxidase responsible for the scavenging of lipid peroxides ( In the last years, Propranolol, a liposoluble non-selective -blocker, without an intrinsic activity ( Apart from the inhibition of ANGPTL4 expression and consequent abrogation of NOX2 activation, Propranolol could also interfere with ferroptosis through the inhibition of cytochrome P450 (CYP450) enzymes, whose activity promotes ROS and lipid peroxidation ( Here, we investigated if ECs activation needed for angiogenesis might be triggered by a ferroptosis-like mechanism
Located at the basal compartment of the seminiferous epithelium, the BTB is primarily formed by junctional complexes between SC, including tight junctions, gap junctions, and basal ectoplasmic specializations ( During spermatogenesis, spermatogonia migrate across the BTB within the seminiferous tubules, the functional units of the mammalian testis
