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Ineffective treatments: Candidates who haven't found relief with traditional treatments, such as oral splints or night guards, might consider injectables

LDH inhibitors such as oxamate or FX-11 lower tumor-microenvironment lactate concentrations (107), In the collagen-induced arthritis (CIA) model, intraperitoneal treatment with the LDHA inhibitor sodium oxamate (100 mg kg -1 day -1 ) reduced intra-articular lactate by 60% and H3K18la by 50%