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Furthermore, evidence from multi-omics studies (Shakt et al., 2024), and the vascular depression hypothesis ( The interaction mechanism between AS and depression is highly complex, involving multiple potential mechanisms, including inflammation (Paranthaman et al., 2012), immune responses (Mousa et al., 2022), autonomic nervous system dysfunction (Pizzi et al., 2010), and intestinal flora and metabolite dysfunction (Wang A

Actin regulation: TB-500's primary mechanism involves upregulating actin, a key structural protein in cells

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- Water-soluble vitamin C is protected from oxidation by fat-soluble vitamin E, aiding in the reduction of oxidized vitamin C