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Non-motor symptoms: the hidden burden Gastrointestinal dysfunction and the gut-brain axis PD may originate in the gut before manifesting in the central nervous system (CNS) through the formation of alpha-synuclein aggregates within the visceral nervous system

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Notably, high doses of Vitamin B (folic acid 0.8 mg, Vitamin B6 20 mg, Vitamin B12 0.5 mg) for 2 years was shown to slow the progression of brain atrophy significantly (Donnelly et al., 2008)

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Presti S., Manti S., Parisi G.F., Papale M., Barbagallo I.A., Li Volti G., Leonardi S