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You may be able to cleave your protein from the GST tag, reducing possible functional interference

During chronic stress, elevated CORT poses a challenge to immune cells

For instance, in a randomized, placebo-controlled trial in healthy adults, subcutaneous CJC-1295 injections produced sustained, dose-dependent increases in GH (two to 10 times) and IGF-1 (1.5 to three times) levels over several days, demonstrating prolonged GH axis stimulation without serious adverse effects, a hormonal milieu associated with anabolic and metabolic effects

Nevertheless, a complete characterization of a functioning cell requires knowledge not only of specificity of biomolecular interactions (i.e., does an interaction occur, or not) but also of affinity (i.e., how strong, in absolute terms, is some given interaction) 6