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Furthermore, at delayed times of incubation, endogenously produced TNF also sustained IB protein expression and C/EBP recruitment, because it operates in cells in which the IL-6 locus has already undergone a reorganization following R848 stimulation

Feng T, Wan J, Li P, Ran H, Chen H, Wang Z, Zhang L

Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor-immunoglobulin fusion protein