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Baser H, Can U, Baser S, Yerlikaya FH, Aslan U, Hidayetoglu BT (2015) Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis

Firstly, there are NO negative effects as you CANNOT take too much

Cells overexpressing HRASV12 or cyclin E1 accumulate R-loops during S and G2 phases of the cell cycle To investigate the molecular mechanisms underlying R-loop formation induced by overexpression of HRASV12 or cyclin E1, we used a U2OS T-REx cell line conditionally expressing catalytically inactive RNase H1 fused to green fluorescent protein [RNH1(D210N)-GFP] 32

It is often called the "master antioxidant" for a very good reason