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(b) dogs with MVD have more serotonin receptors in their valve cells than other dogs

however, it could impair endothelial function via down-regulation of ACE2 and disrupt the integrity of BBB 284,285

Our results of KEGG enrichment analysis showed that PI3K-Akt signaling pathway, FoxO signaling pathway, and AMPK signaling pathway, were enriched with a total of 253, 106, and 91 target genes, respectively