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In colitis, aberrant activation of the MAPK cascade amplifies the production of pro-inflammatory mediators and cytokines, fostering a state of sustained inflammation and tissue damage

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Cell 178:1102-1114e1117 Cignarella F, Cantoni C, Ghezzi L, Salter A, Dorsett Y, Chen L, Phillips D, Weinstock GM, Fontana L, Cross AH, Zhou Y, Piccio L (2018) Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota