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De Vriese AS, Caluw R, Van Der Meersch H, et al

In REDEFINE 1 , a 68-week, Phase 3a, multicenter, double-blind, placebo- and active-controlled trial, 3,417 adults with overweight or obesity but without diabetes were randomized to CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg), semaglutide 2.4 mg, cagrilintide 2.4 mg, or placebo

Effective neuromuscular control ensures that the muscles surrounding the knee joint respond appropriately to dynamic loads and maintain joint stability