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When viewed through the MRIS lens, TRF becomes a behavioral-metabolic intervention, where the simple act of when we eat transforms cellular survival strategies into tangible improvements in cognitive function, emotional resilience, and community reintegration

Primary aliphatic amines are metabolized via the same mechanism, where hydroxylation of the alpha-carbon occurs, followed by rearrangement to release ammonia, and this is termed de-amination (as opposed to N -dealkylation)

Elghareeb MM, et al

The phase separation of tau droplets into gel-like states before transitioning into cytotoxic fibrils that are associated with NDDs is also fueled by the dehydration of hydrophobic protein residues [266, 267]