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Annals of the Rheumatic Diseases

However, multiple factors during dialysis, such as poor biocompatibility, contaminated dialysis water, and immunosuppressive therapy, lead to proinflammatory and prooxidative effects that may adversely affect the aging process (Sturmlechner et al., 2017)

2235 As the mechanisms involved in antioxidant-enzyme interactions are better understood, more information about cellular defense systems and potential therapeutic interventions will emerge