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"Retatrutide, a GIP, GLP-1, and glucagon receptor agonist for obesity: A phase 2 trial." New England Journal of Medicine , 389(6), 514-526

A subsequent larger phase I study in patients with relapsed acute or chronic leukemia (ALL, MDS/AML, or CML) further supported this notion, wherein more than half of the patients demonstrated response to combination therapy ( ex vivo cytokine treatment to activate donor T cells, thereby priming their killing efficacy (cytokine-induced killer [CIK] cells) ( 3.4.6 Leukemia antigen vaccination Other studies have questioned whether the GVL effect of DLI can be promoted by activation of alloreactive T cells in an antigen specific way through individualized vaccination strategies

Methylxanthine Derivatives Pharmacologic Effects Methylxanthines include caffeine, a potent respiratory stimulant, and theobromine, a recognized canine toxicant from chocolate and theophylline (Figure 20-6)

Glutathione S-transferase Glutathione -transferases (GST, EC 2.5.1.18), which first discovered as enzymes in 1961 [12], are abundant proteins encoded by a highly divergent, ancient gene family