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All these results allowed to conclude that APR-246 induces early cell death by ferroptosis, a recently described non-apoptotic form of regulated cell death that links together membrane lipid peroxidation, cysteine and iron metabolism, glutathione peroxidase activity and oxidative stress (as summarized in Figure 4A 2325 )

To better clarify the relevance of cysteine and other thiols in ovarian cancer, we analysed their levels in peripheral blood serum from patients with benign and malignant tumours, from healthy individuals and in ascitic fluid from ovarian cancer patients

Thus, the inhibition of antioxidant enzymes in this pathway also contributes to oxidative stress

Sern, AnnaKaisa Tuomaala, Johan Jendle, Pratik Choudhary, Emanuele Bosi, Viswanathan Mohan, Tim van den Heuvel, Ohad Cohen, Richard F