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While most clinical evidence supports a favorable safety profile at typical therapeutic doses, caution is warranted as higher doses may cause sedation, cardiovascular effects such as hypotension and arrhythmias, and, in rare cases, respiratory depression

Nrf2-deficient mice exposed to CS had more extensive emphysema and more pronounced airway inflammation than wild-type mice

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The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential