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SELENOW expression in the brain of mice has been found to confer protection against oxidative stress-induced neuronal cell death (21)

All cells were cultured in DMEM (HyClone, Cytiva, Marlborough, MA, USA) + 10% FBS (Gibco, Grand Island, NY, USA) and incubated at 37 C in a humidified atmosphere with 5% CO 2

These mutations alone do not initiate tumor formation but act alongside additional genetic changes

The best explanation is that xenobiotics hit the gland directly via the arterial route, whereas ingested toxicants first encounter the liver which is best equipped to deal with RXS, via its huge complement of GSH and GST (21, 170)