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Ethics declarations Competing Interests The authors declare no competing interests

The following sections detail how compromised AT propagates dysfunction through altered adipokine secretion, excessive free fatty acid release, inflammatory mediator production, and EV signaling, establishing self-perpetuating cycles that progressively worsen whole-body metabolic homeostasis

Kim J, Thomas SN

Moreover, direct administration of cysteine to increase GSH is not a viable option, because of its poor absorption and toxicity at high doses (Johnson et al., 2012)