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10.1089/acm.2004.10.1033 26

4.1.3 Quercetin Quercetin, a natural flavonoid widely distributed in plants, has been shown to reduce oxidative stress and promote neurogenesis in animal models of ischemic stroke via antioxidant (136), anti-inflammatory (137), and neuroprotective effects (138)

In parallel, excessive Cu + generated in GSH-rich reductive environments can bind lipoylated mitochondrial TCA-cycle proteins such as DLAT, inducing aberrant protein aggregation and triggering cuproptosis across multiple cancer types 187,189,192-194