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S4), further confirming previous data that 3T3-L1-EVs failed to promote malignant features in BC cells (20) and supporting the notion that functional changes in tumor cells are specifically driven by EVs from differentiated adipocytes

No adverse reactions were found in any of the treatments carried, highlighting a good overall tolerability and absence of local effects like seborrhea, itching or dandruff onset

NOTCH1 -mutated cells rely on glutamine metabolism to sustain their proliferative advantage and show enhanced sensitivity to glutamine inhibition combined with venetoclax Given that metabolic reprogramming is associated with increased tumor survival, proliferation, and aggressiveness [18, 38], we focused on investigating whether an elevated metabolic profile correlated with a growth advantage