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Because IGF1/IGF1r is closely linked to the mTOR pathway, and mTOR is a crucial negative regulator of autophagy, We hypothesize that IGF1 exacerbates autophagic dysfunction through the activation of IGF1r in the TNC brain region, leading to neuronal hyperactivation and the manifestation of headache behaviors

This landmark study demonstrates that Parkin selectively translocates to depolarized mitochondria to promote their autophagic clearance, establishing mitophagy as a quality-control pathway for damaged mitochondria

The 12-month-period prevalence of symptoms of allergic rhinitis in 13- to 14-year-olds varied from 1.4 to 39.7% with a four-fold variation seen between the 10th and 90th percentiles (4.9-21.0%) (Strachan et al., 1997

Not for any other purpose