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(1973) Studies on S-adenosylhomocysteine inhibition of histamine transmethylation in brain, J

Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: a possible role for NGF in the pathogenesis of diabetic neuropathy

Compared to 108 control subjects without evidence of dementia, subjects with dementia of Alzheimer's type and confirmed Alzheimer's disease had higher blood levels of homocysteine and lower blood levels of folate and vitamin B 12

Note that if your dog has been diagnosed with inflammatory bowel disease (IBD) or another chronic GI disorder, treatments for that underlying condition may not be effective until a healthy B12 level has been restored