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Utility study: Synthesized CBV maps aging effects over the entire cortex The GBCA-predicted maps were generated in the native space of each participant and were afterward used for CBV quantification together with the experimentally acquired ground truth GBCA-uptake maps using the same whole brain top 10% mean normalization

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LC-MS based non-targeted analysis was then performed, where DnsBank was employed for spectrum matching and molecule annotation

Programmed cell death and Bcl-2 protection in very low oxygen