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Absorbance at 410 nm was measured once every minute at 7 time points using Microplate Spectrophotometer PowerWave XS(BioTek Instruments, Winooski, VT, USA)

Moreover, SuperScript IV (SSIV) showed no significant change in any mutation types compared to TGIRT (Supplementary Fig

ALIMTA was administered intravenously over 10 minutes at a dose of 500 mg/m2 on Day 1 of each 21-day cycle