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393,394 Thus, the mechanisms underlying the regulatory role of SIRT1 in DNA repair and gene transcription in cancer development need further exploration

Kelstrup, C

It has, however, been linked to alterations in the hypothalamic-pituitary-adrenal axis

Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes