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The increased MAO-A levels in chronic social stress result in decreased serotonin and dopamine release, playing a role in depression from chronic stress.[ref] MAO-A, MAOIs, and Tyramine: MAO enzymes, particularly MAO-A , are involved in the breakdown of tyramine, a naturally occurring amine found in certain foods

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The results indicated that KMO inhibition was able to reduce significantly the extent of leukocyte infiltration into the brain as well as the histological assessment of neuronal death