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Future research must address long-term toxicity profiles, the scalability of nano-manufacturing, and the standardization of regulatory approval pathways for nano-nutraceuticals. To facilitate clinical feasibility, subsequent studies should prioritize the integration of pharmacodynamic biomarkers, quantitative BBB penetration analysis, and rigorous safety profiling to establish standardized clinical dosing strategies

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They systematically target three critical nodes: iron homeostasis, lipid peroxidation, and the SLC7A11-GPX4 antioxidant axis