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The induction of murine liver carcinogenesis secondary to phenobarbital enzyme induction shows considerable strain susceptibility and is causally associated with activation of the CAR receptor

Additionally, MSC-derived exosomes enriched in miRNAs such as miR-21 downregulate apoptotic regulators including PTEN and PDCD4, activate the PI3KAkt survival pathway, and alleviate oxidative stress [25]

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