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Materials and Methods Participants The current study protocol was approved by the Institutional Review Board at the University of North Texas and all aspects of the study were conducted in accordance with the Declaration of Helsinki

In this study, despite the limitations described, our observations highlight significant proteomic changes in chondrocytes under oxidative stress, including ER dysfunction and impaired ECM protein secretion, offering a deeper understanding of how redox imbalances affect chondrocyte function

After one, three, and six months, subjects returned to the clinic to return their unused capsules and receive new capsules

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