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Exp Neurol 244:410

We also found that auranofin is an efficient inhibitor of pure TGR ( K i = 10 nM), able to kill parasites rapidly in culture at physiological concentrations (5 M), and able to partially cure infected mice (worm burden reductions of ~60%)

In recent years, more and more studies on UPS have been conducted, and we have recognized that UPS can play an important role in various renal diseases such as renal cell carcinoma[3], acute kidney injury[4], and renal fibrosis[5] through a variety of mechanisms