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As a result, numerous researchers have dedicated themselves to investigating the mechanism of platinum drugs to prevent or lessen their toxic effects.Studies indicate that numerous chemical drugs and herbs possess the capability to hinder oxidative stress caused by cisplatin by eradicating free radicals and increasing the activity of antioxidant enzymes, ultimately providing reproductive and genotoxic protection against cisplatin

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All animal experiments were approved by and conducted in compliance with Institutional Animal Care and Use Committee (IACUC) of the University of Colorado Anschutz Medical Campus