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The hosts immune system actively uses PRR-driven signaling to influence the bone marrow niche, while bacterias colonization and proprietary metabolic activity are controlled by the intestinal mucosal immunity system (such as B cell-produced secretory IgA)

Based on this, we can propose a clear copper peptide serum development roadmap and sampling plan

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However, as multiple factors are involved in the development of AD, more pathways related to the disease pathogenesis need to be further investigated