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He states that there are a range of unpleasant side effects, and that is not needed if a person is already taking estrogen and/or testosterone via hormone replacement therapy (HRT)

Qiu Y, Liu S, Chen HT, Yu CH, Teng XD, Yao HT, Xu GQ (2013) Upregulation of caveolin-1 and SR-B1 in mice with non-alcoholic fatty liver disease

The following reviewer(s) agreed to reveal their identity: Toni Pak Although I am accepting as is, when you get the proofs, please make the following corrections: 1

Some animal model studies have established no difference in atherosclerotic lesion size between specific pathogen-free (conventionally raised, CONV-R) and germ-free (GF) mice on a high-fat diet (HFD) (14, 18), while others have noted bigger atherosclerotic lesion sizes in GF mice than in CONV-R mice on chow (18, 19)